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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Related Experiment Video

Updated: Jun 25, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Ewing sarcoma presenting as a subconjunctival mass.

Katherine A Lane1, James A Katowitz

  • 1Children's Hospital of Philadelphia, University of Pennsylvania Hospital System, Philadelphia, Pennsylvania 19104-4399, USA. katelane@verizon.net

Ophthalmic Plastic and Reconstructive Surgery
|March 11, 2009
PubMed
Summary
This summary is machine-generated.

A rare orbital Ewing sarcoma was diagnosed in a 14-year-old boy with a growing subconjunctival mass. This primary orbital tumor showed no signs of metastasis at diagnosis.

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Surgical Treatment of an Endolymphatic Sac Tumor
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Last Updated: Jun 25, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

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04:34

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Published on: May 26, 2023

Area of Science:

  • Oncology
  • Ophthalmology
  • Pediatric Pathology

Background:

  • Ewing sarcoma is a rare and aggressive bone and soft tissue cancer.
  • Orbital involvement is uncommon, especially as a primary presentation without metastasis.

Observation:

  • A 14-year-old boy presented with a subconjunctival mass that enlarged over time.
  • Imaging revealed a gadolinium-enhancing anterior orbital lesion.

Findings:

  • Excisional biopsy showed small, blue, round tumor cells characteristic of malignancy.
  • Immunohistochemistry was positive for CD99, CD56, and retained INI-1.
  • RT-PCR confirmed the EWS-FLI1 fusion gene, diagnostic of Ewing sarcoma.
  • Systemic staging (CT, bone scan, bone marrow biopsy) was negative for metastasis.

Implications:

  • This case highlights a rare presentation of primary orbital Ewing sarcoma.
  • Early diagnosis and complete excision are crucial for managing localized orbital tumors.
  • Further research into the specific behavior of orbital Ewing sarcoma is warranted.