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Related Concept Videos

Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...
Carbon Skeletons01:12

Carbon Skeletons

Life on Earth is carbon-based, as all macromolecules that make up living organisms contain carbon atoms. All organic compounds have a carbon backbone. Each carbon atom is tetravalent and can bond with four other atoms, making it an extraordinarily flexible component of biological molecules. Because carbon’s valence electrons are stable, it rarely becomes an ion. As the carbon chain increases in length, structural modifications such as ring structures, double bonds, and branching side chains...
Molecular Models02:00

Molecular Models

Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.

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Related Experiment Video

Updated: Jun 25, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

Skeletally diverse small molecules using a build/couple/pair strategy.

Takuya Uchida1, Manuela Rodriquez, Stuart L Schreiber

  • 1Howard Hughes Medical Institute, Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.

Organic Letters
|March 12, 2009
PubMed
Summary

Researchers developed a new three-step synthetic pathway using catalytic, stereoselective cross-Mannich reactions. This method efficiently creates skeletally diverse small molecules with potential for significant stereochemical variation.

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Last Updated: Jun 25, 2026

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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
10:17

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

Area of Science:

  • Organic Chemistry
  • Synthetic Chemistry
  • Medicinal Chemistry

Background:

  • Small molecule synthesis is crucial for drug discovery and materials science.
  • Developing efficient and stereoselective synthetic routes remains a key challenge.
  • Accessing diverse molecular skeletons is essential for exploring chemical space.

Purpose of the Study:

  • To explore a novel synthetic route to skeletally diverse small molecules.
  • To utilize catalytic, stereoselective cross-Mannich reactions for molecular construction.
  • To investigate the potential for stereochemical diversification in the synthesized products.

Main Methods:

  • Employing intermolecular catalytic, stereoselective cross-Mannich reactions.
  • Utilizing intramolecular functional group-pairing reactions on Mannich products.
  • Synthesizing small molecules through a concise, multi-step pathway.

Main Results:

  • Successfully generated 12 different molecular skeletons.
  • Achieved skeletal diversity in only three synthetic steps.
  • Demonstrated a viable route for accessing complex small molecules.

Conclusions:

  • The developed synthetic pathway offers an efficient method for creating skeletally diverse small molecules.
  • The strategy holds significant potential for future stereochemical diversification.
  • This approach provides a valuable tool for accessing novel chemical entities.