Related Experiment Video
Updated: Jun 25, 2026

Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3
Published on: April 7, 2023
New approved dasatinib regimen available for clinical use
1City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA 91010, USA. dsnyder@coh.org
Abstract:
Dasatinib, a tyrosine kinase inhibitor of BCR-ABL, was originally approved for the second-line treatment of any-phase chronic myelogenous leukemia (CML) or Philadelphia chromosome-positive acute lymphoblastic leukemia at a dosage of 70 mg twice daily. In chronic-phase (CP) CML resistant to first-line imatinib, this regimen is more efficacious than high-dose imatinib. A Phase III study of CP CML has now shown that dasatinib 100 mg once daily is therapeutically noninferior to 70 mg twice daily and has an improved safety profile. Patients receiving dasatinib 100 mg once daily suffered significantly fewer thrombocytopenia (grade 3-4) and pleural effusion (all grades) events than those receiving dasatinib 70 mg twice daily. Fewer patients receiving dasatinib 100 mg once daily also required dose interruption/reduction or discontinuation. The recommended regimen for dasatinib in patients with CP disease and who are resistant or intolerant to primary therapy with imatinib is now 100 mg once daily.
Related Concept Videos
Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
FDA Approved Drugs: Changes to Approved Drugs
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme (ECE). Of...
Therapeutic Drug Monitoring: Overview and Classification
Treatment Resistent Cancers
Dipeptidyl Peptidase 4 Inhibitors