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Radiopharmaceuticals for oncology drug development: a pharmaceutical industry perspective

Philip S Murphy1, Mats Bergström

  • 1Oncology Research and Development, GlaxoSmithKline, Uxbridge, Middlesex, UB11 1BT, UK. philip.s.murphy@gsk.com

Current Pharmaceutical Design
|March 12, 2009
PubMed

Insights

Radiopharmaceuticals aid oncology drug development by assessing treatment response and providing molecular insights. Novel tracers can improve early decision-making and de-risk late-stage programs.

Area of Science:

  • Oncology
  • Radiopharmaceutical Development
  • Drug Discovery

Background:

  • Oncology drug development faces scientific and operational challenges.
  • Radiopharmaceuticals offer methodologies to support various stages of drug development.
  • Current methods like FDG-PET assess metabolic response, but advancements are needed.

Purpose of the Study:

  • To highlight the role of radiopharmaceuticals in overcoming drug development bottlenecks.
  • To discuss the potential of novel radiotracers in oncology.
  • To emphasize matching tracer development with drug development needs.

Main Methods:

  • Utilizing established tracers like (18F)-FDG-PET for metabolic response assessment.
  • Exploring improved tracers such as (18F)-FLT for specific applications.
  • Investigating new molecularly targeted tracers for angiogenesis and apoptosis.
  • Employing labeled drugs for in vivo pharmacokinetic studies.

Main Results:

  • Radiotracers like (18F)-FDG-PET evaluate early treatment response.
  • (18F)-FLT offers improvements in certain clinical development settings.
  • Emerging tracers provide molecular insights, reducing ambiguity in drug efficacy.
  • Labeled drugs enable in vivo pharmacokinetic and combination therapy studies.

Conclusions:

  • Radiopharmaceuticals are crucial tools for efficient oncology drug development.
  • Novel tracers targeting processes like angiogenesis and apoptosis will support early decision-making and de-risk late-stage programs.
  • Strategic development of new tracers must align with evolving drug development requirements due to significant investment costs.

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