Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
In Vitro Fertilization01:24

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
CRISPR01:59

CRISPR

Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced Short...
Meiosis vs. Mitosis02:57

Meiosis vs. Mitosis

Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Reproductive Cloning01:27

Reproductive Cloning

Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic cell—any cell that is not a sex...
Nondisjunction01:21

Nondisjunction

Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold sister...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Maternal exposure to fine particulate matter and pregnancy outcomes in women undergoing <i>in vitro</i> fertilization: A multicenter retrospective study.

Eco-Environment & Health·2026
Same author

Melatonin enhances vitrified mouse blastocyst development by mitigating oxidative stress and preserving mitochondrial function.

Molecular human reproduction·2025
Same author

Identification and Validation of RPL7 and RCCD1 as Potential Biomarkers Associated with Immune Infiltration in Patients with Thin Endometrium.

Reproductive sciences (Thousand Oaks, Calif.)·2025
Same author

Condensate-forming eIF4ET ensures adequate levels of meiotic proteins to support oocyte storage.

Life science alliance·2025
Same author

Melatonin Rescues Hyperacetylation of Liver and Impaired Enzymatic Activities of Mitochondrial in IVF Offspring.

Reproductive sciences (Thousand Oaks, Calif.)·2025
Same author

Association between female waist-hip ratio and live birth in patients undergoing <i>in vitro</i> fertilization: a retrospective cohort study.

Frontiers in endocrinology·2025
Same journal

Management of hypertensive disorders in pregnancy.

Current opinion in obstetrics & gynecology·2026
Same journal

Updates in group prenatal care research.

Current opinion in obstetrics & gynecology·2026
Same journal

Complex benign gynecology in perimenopause: current evidence and future directions.

Current opinion in obstetrics & gynecology·2026
Same journal

Role of insulin in female reproduction.

Current opinion in obstetrics & gynecology·2026
Same journal

Urinary tract involvement in endometriosis: current evidence and clinical insights into navigating diagnosis and management.

Current opinion in obstetrics & gynecology·2026
Same journal

Updates in ultrasound imaging of adenomyosis and clinical impacts.

Current opinion in obstetrics & gynecology·2026
See all related articles

Related Experiment Video

Updated: Jun 25, 2026

Monitoring Blood Glucose in Mouse Offspring After Intracytoplasmic Sperm Injection
06:11

Monitoring Blood Glucose in Mouse Offspring After Intracytoplasmic Sperm Injection

Published on: May 17, 2024

Does assisted reproductive technology cause birth defects?

Orhan Bukulmez1

  • 1Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Florida College of Medicine, 1600 SW Archer Rd, Gainesville, FL 32610-0294, USA. obukulmez@ufl.edu

Current Opinion in Obstetrics & Gynecology
|March 12, 2009
PubMed
Summary
This summary is machine-generated.

Assisted reproductive technology (ART) pregnancies may have a slightly increased risk of birth defects, but this is likely linked to parental infertility factors, not ART itself. Further research is needed to clarify the association between ART and adverse offspring outcomes.

More Related Videos

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
09:03

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis
12:32

Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis

Published on: September 7, 2021

Related Experiment Videos

Last Updated: Jun 25, 2026

Monitoring Blood Glucose in Mouse Offspring After Intracytoplasmic Sperm Injection
06:11

Monitoring Blood Glucose in Mouse Offspring After Intracytoplasmic Sperm Injection

Published on: May 17, 2024

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
09:03

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis
12:32

Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis

Published on: September 7, 2021

Area of Science:

  • Reproductive Medicine
  • Genetics
  • Obstetrics

Background:

  • Observational studies indicate a potential link between assisted reproductive technology (ART) and increased birth defect risks.
  • However, a definitive consensus remains elusive due to inherent biases in existing data.

Purpose of the Study:

  • To review current data on the association between ART and birth defects.
  • To provide essential information for counseling patients undergoing fertility treatments.

Main Methods:

  • Review of observational studies and recent reports on ART outcomes.
  • Analysis of data concerning birth defects, genetic, and imprinting disorders.

Main Results:

  • Lack of consensus on ART per se increasing birth defect risk; studies suggest 30-40% higher risk.
  • Apparent ART-related risks may be attributed to parental infertility factors.
  • Challenges exist in defining and diagnosing birth defects.

Conclusions:

  • Counseling should address potential risks associated with infertility and ART.
  • Multinational collaborative studies with large sample sizes (10,000–84,000+) are required to resolve the ART-adverse outcome controversy.