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Published on: March 17, 2014
Parasitic lung infections
1Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India. vijayanvk@hotmail.com
Purpose Of Review:
Global climate change and population explosion leading to changes in natural ecosystem and travel across the continents have resulted in an increase in the transmission of parasites to human beings. This review focuses on recent advancements in parasitic lung infections.
Recent Findings:
Invasive parasitic diseases including lung infections are increasingly being reported in patients with immunodeficiency syndromes. A recombinant kinesin-related antigen of Leishmania donovani has been validated with ELISA using urine samples for the diagnosis of visceral leishmaniasis. Pyruvate kinase deficiency has been shown to provide protection against Plasmodium falciparum infection. Intravenous artesunate is an alternative drug for the treatment of severe malaria. The best way to protect from malaria is the use of long-lasting insecticide-treated bednets. Biennial treatment with praziquantel has been found to be cost-effective treatment for control of infection with Schistosoma haematobium. Pulmonary paragonimiasis can be diagnosed by fine needle aspiration biopsy of pulmonary nodules. Strongyloides stercoralis hyperinfection can mimic accelerated idiopathic pulmonary fibrosis. Migratory nodular shadows with halos are important chest computed tomographic findings in human toxocariasis.
Summary:
Patients with immunodeficiency syndromes (HIV infection, organ transplantation and immunosuppressive drugs, including corticosteroids) should be evaluated for early detection of parasitic lung infections.
Insights
Parasitic lung infections are rising due to climate change and travel. Early detection in immunocompromised patients is crucial for managing these invasive diseases.
Area of Science:
- Medical Parasitology
- Infectious Diseases
- Pulmonology
Background:
- Global climate change, population growth, and increased travel contribute to the spread of parasitic infections.
- Parasitic lung infections are a growing concern, particularly in individuals with compromised immune systems.
Purpose of the Study:
- To review recent advancements in the diagnosis and treatment of parasitic lung infections.
- To highlight the importance of early detection in immunocompromised patients.
Main Methods:
- Review of recent literature on parasitic lung infections.
- Discussion of diagnostic tools such as ELISA, fine needle aspiration biopsy, and chest CT scans.
- Overview of treatment strategies for various parasitic lung infections.
Main Results:
- Invasive parasitic lung infections are increasingly reported in patients with immunodeficiency syndromes.
- New diagnostic methods for leishmaniasis and improved treatment for malaria and schistosomiasis have emerged.
- Specific parasitic infections like Strongyloides stercoralis and toxocariasis present unique diagnostic challenges in the lungs.
Conclusions:
- Immunocompromised patients (e.g., those with HIV, organ transplants, or on immunosuppressive drugs) require prompt evaluation for parasitic lung infections.
- Early diagnosis and management are essential for improving outcomes in patients with parasitic lung infections.
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