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Related Experiment Video

Updated: Jun 24, 2026

Optimized Procedure for Determining the Adsorption of Phosphonates onto Granular Ferric Hydroxide using a Miniaturized Phosphorus Determination Method

Optimized Procedure for Determining the Adsorption of Phosphonates onto Granular Ferric Hydroxide using a Miniaturized Phosphorus Determination Method

Published on: May 18, 2018

Oral phosphate binders.

Alastair J Hutchison¹

¹Manchester Institute of Nephrology and Transplantation, The Royal Infirmary, Manchester, UK. alastair.hutchison@cmft.nhs.uk

Kidney International

|March 13, 2009

Summary

This summary is machine-generated.

Hyperphosphatemia in dialysis patients is linked to higher cardiovascular mortality. Current phosphate binders have limitations, and long-term outcome data are lacking, necessitating further research into effective treatments.

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High-Throughput Measurement and Classification of Organic P in Environmental Samples

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Last Updated: Jun 24, 2026

Optimized Procedure for Determining the Adsorption of Phosphonates onto Granular Ferric Hydroxide using a Miniaturized Phosphorus Determination Method

Optimized Procedure for Determining the Adsorption of Phosphonates onto Granular Ferric Hydroxide using a Miniaturized Phosphorus Determination Method

Published on: May 18, 2018

High-Throughput Measurement and Classification of Organic P in Environmental Samples

High-Throughput Measurement and Classification of Organic P in Environmental Samples

Published on: June 8, 2011

Area of Science:

Nephrology
Cardiovascular Medicine
Pharmacology

Background:

Hyperphosphatemia is common in end-stage chronic kidney disease (CKD) patients undergoing dialysis.
It is associated with increased cardiovascular mortality in this population.
Dietary phosphate restriction and dialysis are often insufficient to control serum phosphate levels.

Purpose of the Study:

To review the effectiveness and safety of oral phosphate binders in dialysis patients.
To discuss the limitations of conventional phosphate binders.
To highlight the need for prospective, outcome-based trials.

Main Methods:

Review of existing literature on hyperphosphatemia management in dialysis patients.
Analysis of safety and efficacy data for various phosphate binders.
Discussion of current treatment guidelines and research gaps.

Main Results:

Conventional phosphate binders (calcium-based, sevelamer, lanthanum carbonate) have varying degrees of effectiveness, side effects, and limitations (e.g., pill burden, cost, vascular calcification concerns).
Aluminum-based binders are effective but toxic.
Long-term outcome data and prospective trials are limited.

Conclusions:

Current phosphate binders present challenges in managing hyperphosphatemia in dialysis patients.
There is a critical need for well-designed, prospective, randomized controlled trials to evaluate the impact of phosphate binder therapy on patient outcomes.
Improving patient outcomes in dialysis, which are worse than many cancers, requires a focus on evidence-based treatment strategies.