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Minor malformations, hyperactivity, and learning disabilities.

P J Accardo1, T Tomazic, J Morrow

  • 1Department of Pediatrics, St Louis University School of Medicine, Knights of Columbus Developmental Center, Cardinal Glennon Children's Hospital St. Louis, MO.

American Journal of Diseases of Children (1960)
|October 1, 1991
PubMed
Summary
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Standardized minor malformation scores do not predict hyperactivity or attention deficits in children. Instead, higher scores are linked to learning disabilities and higher IQs, suggesting a different diagnostic utility.

Area of Science:

  • Developmental Pediatrics
  • Clinical Genetics
  • Neurodevelopmental Disorders

Background:

  • Standardized minor malformation scores have been suggested as predictors for attention problems and hyperactivity.
  • The utility of these scores for identifying specific neurodevelopmental profiles remains incompletely understood.

Purpose of the Study:

  • To investigate the diagnostic correlations of minor malformation scores in children evaluated for developmental disorders.
  • To determine the association between dysmorphology scores and diagnoses such as attention deficit hyperactivity disorder and learning disabilities.

Main Methods:

  • Examined minor malformation scores in 1233 children undergoing multidisciplinary evaluation for developmental disorders.
  • Excluded children with chromosomal disorders and recognized dysmorphic syndromes.

Related Experiment Videos

  • Analyzed correlations between dysmorphology scores, IQ, hyperactivity, attention deficit disorder, and specific learning disabilities.

    • Main Results:

    • No significant association was found between minor malformation scores and hyperactivity or attention deficit disorder.
    • Higher dysmorphology scores were observed in children with IQs greater than 100.
    • Children with specific learning disabilities exhibited significantly higher minor malformation scores.

    Conclusions:

    • Minor dysmorphic features do not reliably predict attentional problems or hyperactivity in referred children.
    • Elevated minor malformation scores may characterize children with co-occurring attention deficit disorder and learning disabilities, or learning disabilities alone.