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Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

Changes in the Appendicular Skeleton with Age

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

[Bone tumor frequency in adults and elderly].

Eréndira G Estrada-Villaseñor¹, José F Flores-Carmona, Ernesto Andrés Delgado-Cedillo

¹Depto. de Anatomía Patológica, Instituto Nacional de Rehabilitación, Calzada México Xochimilco Núm. 289, Col. Arenal de Guadalupe, Delegación Tlalpan, C. P. 14389, DF México. eestrada@inr.gob.mx

Acta Ortopedica Mexicana

|March 14, 2009

Summary

This study analyzed bone tumors and tumor-like lesions in adults and the elderly. Metastases were most common in those over 60, while plasmocytoma/myeloma and giant cell tumors were more frequent in those aged 40-60.

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Area of Science:

Oncology
Orthopedics
Pathology

Context:

Bone tumors and tumor-like lesions represent a growing health concern in aging populations.
Understanding the epidemiology of these conditions is crucial for effective healthcare planning.

Purpose:

To analyze the frequency of bone tumors and tumor-like lesions in adults and the elderly.
To identify differences in tumor types between age groups (40-60 and >60 years).
To determine the most common sites of bone tumor involvement.

Summary:

A retrospective review of bone tumors and tumor-like lesions in patients over 40 from 2000-2006 was conducted.
In patients aged 40-60, plasmocytoma/myeloma (19.4%), giant cell tumor (14.1%), and metastases (12.3%) were most frequent.
In patients over 60, metastases (37.2%), plasmocytoma/myeloma (11.8%), and malignant fibrous histiocytoma (6.7%) predominated, with significant group differences observed.

Impact:

Provides epidemiological data on bone tumors in older adults, aiding in diagnosis and treatment strategies.
Highlights age-related variations in bone tumor prevalence, informing targeted research and clinical management.
Contributes to understanding the burden of bone neoplasms in the elderly population.