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Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

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Related Experiment Video

Updated: Jun 24, 2026

Three-Dimensionally Printed Microfluidic Cross-flow System for Ultrafiltration/Nanofiltration Membrane Performance Testing

Three-Dimensionally Printed Microfluidic Cross-flow System for Ultrafiltration/Nanofiltration Membrane Performance Testing

Published on: February 13, 2016

[Cascade hemofiltration: principle, first experimental data].

T Rimmelé¹, D Hayi-Slayman, M Page

¹Département d'anesthésie-réanimation, pavillon P réanimation, hôpital Edouard-Herriot, hospices civils de Lyon, 5 place d'Arsonval, Lyon, France. thmrimmele@aol.com

Annales Francaises D'Anesthesie Et De Reanimation

|March 14, 2009

Summary

This summary is machine-generated.

Cascade hemofiltration is a novel system designed to overcome drawbacks of high-volume hemofiltration in septic shock treatment. Early studies show it is technically feasible, safe, and secure.

Related Experiment Videos

Last Updated: Jun 24, 2026

Three-Dimensionally Printed Microfluidic Cross-flow System for Ultrafiltration/Nanofiltration Membrane Performance Testing

Three-Dimensionally Printed Microfluidic Cross-flow System for Ultrafiltration/Nanofiltration Membrane Performance Testing

Published on: February 13, 2016

Area of Science:

Nephrology
Intensive Care Medicine
Biomedical Engineering

Background:

High-volume hemofiltration (HVHF) is explored for septic shock, offering renal support and immunomodulation by removing middle molecules like cytokines.
HVHF has drawbacks: depletion of essential low molecular weight molecules, high costs, and increased nursing demands.
Septic shock management requires effective renal support and host response modulation.

Purpose of the Study:

To introduce and evaluate cascade hemofiltration, a new HVHF system designed to mitigate the limitations of conventional HVHF.
To assess the technical feasibility, safety, and security of the cascade hemofiltration system in an initial experimental study.

Main Methods:

Development of a novel extracorporeal circuit for cascade hemofiltration.
Experimental study to evaluate the prototype's performance, safety, and security.
Focus on addressing the depletion of low molecular weight molecules and reducing resource burden.

Main Results:

The cascade hemofiltration system demonstrated technical feasibility.
The system proved to be secure and safe in the initial experimental setting.
The novel circuit design shows potential for overcoming HVHF drawbacks.

Conclusions:

Cascade hemofiltration presents a promising alternative to conventional HVHF for septic shock.
Further experimental and clinical studies are necessary to fully validate the system's efficacy and benefits.
The system warrants continued investigation for improved septic shock management.