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Updated: Aug 23, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Suboptimal exposure to fluconazole in critically ill patients: Pharmacokinetic analysis and determinants
A L Bienvenu1, P Pradat2, E Matusik3
1Service Pharmacie, Groupement Hospitalier Nord, Hospices Civils de Lyon, Lyon, France; ICBMS CNRS 5246, Campus Lyon-Tech La Doua, Université de Lyon, Lyon, France.
Objectives:
This study aims at evaluating fluconazole exposure in critically ill patients and identifying variables associated with the latter.
Patients And Methods:
This was a 2-year (2018-2019) retrospective multicenter cohort study. Adult patients > 18 years-old with at least one fluconazole concentration measurement during their ICU stay were included.
Results:
Twenty patients were included. Only 11 patients had a fluconazole trough concentration (Cmin) within the target range (≥15 mg/L). According to bivariable analysis, SOFA score, GGT, fluconazole clearance, Ke, and Vd, were independently associated with a decrease in fluconazole Cmin. The median loading dose required to achieve the Cmin target appeared to be greater in patients with higher SOFA or GGT level and in patients undergoing renal replacement therapy.
Conclusions:
This study supports recommendation for routine fluconazole therapeutic drug monitoring in ICU patients so as to avoid underexposure, especially if SOFA score is ≥ 7 and/or GGT is ≥ 100 U/L.
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