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Updated: Sep 25, 2025

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
Published on: November 9, 2016
[NRFit: A new standard to prevent wrong-route medication errors]
C-H Vacheron1, V Piriou2, O Untereiner3
1Département d'anesthésie réanimation, Hospice Civil de Lyon, Centre Hospitalier Lyon-Sud, Lyon, France; Hospices civils de Lyon, Pôle santé publique, service de biostatistique-Bioinformatique, Lyon, France; Université Claude Bernard Lyon 1, Faculté de Médecine, Lyon, France; Comité analyse et maîtrise du Risque, SFAR, Paris, France.
Abstract:
Wrong route medication errors due to tubing misconnections can lead to serious adverse events, especially when they concern the neuraxial and perineural routes. It has been favoured by the use of the universal Luer connector for medical devices with a risk of confusion with the intravenous route. The prevention of these errors is based on passive measures such as using specific small-bore connectors, and active measures such as reading Specific labelling which must be systematically affixed to the routes. NRFit connectors are a type of small-bore connector specifically intended for neuraxial and perineural applications. They are based on the International Organization for Standardization (ISO) standard 80369-6. They are physically incompatible with other small-bore connectors, like the Luer connectors used for intra-venous and enteral medication administration, and thus help prevent inadvertent misconnections. While some countries have already implemented this standard, France is behind schedule in implementing the NRFit connectors due to the absence of strong recommendations or obligations from the authorities. However, NRFit connectors represents real progress for the prevention of medication errors.
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