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Related Concept Videos

Routes of Drug Administration: Overview01:22

Routes of Drug Administration: Overview

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Drug administration involves delivering drugs to the body through various routes, such as enteral, parenteral, and topical.
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
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Routes of Drug Administration: Parenteral01:25

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The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
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Additional Routes of Drug Administration01:18

Additional Routes of Drug Administration

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Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
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Guidelines for Nursing Documentation I01:30

Guidelines for Nursing Documentation I

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Quality documentation and reporting share essential characteristics that ensure they are practical and valuable resources for those who use them. These characteristics are:
Factual:  
The following points emphasize the significance of upholding accurate and unbiased documentation in healthcare.
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Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

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In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
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Guidelines and Strategies for Safe Computer Charting01:18

Guidelines and Strategies for Safe Computer Charting

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The guidelines and strategies provided by the American Nurses Association (ANA) and the Canadian Nurses Association (CNA) offer essential principles for ensuring safe and secure computer charting systems in healthcare settings. Let's break down each recommendation:
Maintain Confidentiality and Security:
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Related Experiment Video

Updated: Sep 25, 2025

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
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A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

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[NRFit: A new standard to prevent wrong-route medication errors].

C-H Vacheron1, V Piriou2, O Untereiner3

  • 1Département d'anesthésie réanimation, Hospice Civil de Lyon, Centre Hospitalier Lyon-Sud, Lyon, France; Hospices civils de Lyon, Pôle santé publique, service de biostatistique-Bioinformatique, Lyon, France; Université Claude Bernard Lyon 1, Faculté de Médecine, Lyon, France; Comité analyse et maîtrise du Risque, SFAR, Paris, France.

Annales Pharmaceutiques Francaises
|May 1, 2022
PubMed
Summary
This summary is machine-generated.

Wrong route medication errors, particularly with neuraxial and perineural routes, can be prevented by using NRFit connectors. These specialized connectors, based on ISO 80369-6, ensure safer drug administration by preventing misconnections.

Keywords:
Anesthésie loco-régionaleConnecteurs de petit calibreISO 83069 standardNRFit systemNorme ISO 83069Patient safetyRegional block proceduresSmall-bore connectorsSystème NRFitSécurité du patient

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Area of Science:

  • Medical Device Safety
  • Patient Safety
  • Pharmacovigilance

Context:

  • Tubing misconnections pose significant risks for medication errors, especially in neuraxial and perineural drug administration.
  • The universal Luer connector's compatibility with various medical devices increases the risk of confusion with intravenous routes.
  • Current prevention strategies include passive measures like specialized connectors and active measures like route-specific labeling.

Purpose:

  • To highlight the role of NRFit connectors in preventing wrong-route medication errors.
  • To emphasize the importance of adopting ISO 80369-6 standards for neuraxial and perineural applications.
  • To address the delayed implementation of NRFit connectors in France.

Summary:

  • NRFit connectors are designed for neuraxial and perineural applications, adhering to ISO 80369-6 standards.
  • Their physical incompatibility with Luer connectors prevents inadvertent misconnections, a common cause of medication errors.
  • Despite proven benefits, France faces delays in NRFit connector adoption due to a lack of regulatory mandates.

Impact:

  • NRFit connectors represent a significant advancement in reducing medication errors and improving patient safety.
  • Widespread adoption of NRFit connectors can enhance the safety of neuraxial and perineural drug administration.
  • Standardization and regulatory support are crucial for the successful implementation of NRFit connectors globally.