Related Experiment Video
Updated: Jun 24, 2026
12:50
Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
Published on: September 15, 2017
CD154 and its receptors in inflammatory vascular pathologies
Ghada S Hassan1, Yahye Merhi, Walid M Mourad
1Laboratoire d'Immunologie Cellulaire et Moléculaire, Centre Hospitalier de l'Université de Montréal, Hôpital Saint-Luc, Montréal, QC H2X 1P1, Canada.
Trends in Immunology
|March 14, 2009
Summary
CD154, a tumor necrosis factor-alpha family member, plays a key role in vascular diseases like atherosclerosis. Blocking CD154 or its receptor CD40 can prevent these conditions.
Area of Science:
- Immunology
- Vascular Biology
- Cellular Biology
Background:
- CD154 (tumor necrosis factor-alpha family) is implicated in vascular disease pathophysiology.
- CD154 blockade in mice prevents atherosclerosis and atherothrombosis.
- CD154 interacts with CD40, alphaIIbbeta3 integrin, alpha5beta1 integrin, and Mac-1.
Purpose of the Study:
- To illustrate the functional features of CD154 receptors.
- To describe the role of CD40 in CD154-associated vascular pathologies.
Main Methods:
- Review of existing literature and functional studies.
- Analysis of CD154 interactions with various receptors.
- Examination of CD40's role in atherosclerosis and atherothrombosis.
Main Results:
- CD154 blockade prevents atherosclerosis and atherothrombosis.
- CD154 binds to CD40, alphaIIbbeta3 integrin, alpha5beta1 integrin, and Mac-1.
- These interactions contribute to platelet activation and vascular disease.
Conclusions:
- CD154 and its receptors, particularly CD40, are critical in vascular pathologies.
- Targeting CD154 or CD40 may offer therapeutic strategies for atherosclerosis and atherothrombosis.
Related Concept Videos
01:30Inflammatory Response I: Vascular and Cellular
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
01:17Intracellular Signaling Affects Focal Adhesions
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Some...
01:28Inflammatory Response
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
01:38Inflammation
Overview
01:24Regulation of Angiogenesis and Blood Supply
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
01:24Inflammatory Response II: Inflammatory Exudate and Tissue Repair
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the exudate's...
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the exudate's...