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Updated: Jun 24, 2026

Viral Tracing of Genetically Defined Neural Circuitry
Published on: October 17, 2012
The rabies virus phosphoprotein synthesis and subcellular localization are modified by nerve growth factor
Nadia Y Castaneda1, Jacqueline Chaparro-Olaya, Orlando Acosta
1Instituto de Virologia, Universidad El Bosque, Bogota, Colombia.
Abstract:
Rabies virus P protein participates as a regulating factor in viral transcription and replication; recent studies found an antitranscriptional and antireplicative effect of nerve growth factor (NGF) and Neurotrophin-3 (NT-3) in infected neuron cultures. We investigated here the specific effect of the neurotrophins on P protein, evaluating its synthesis and subcellular distribution in adult mouse dorsal root ganglia neuron cultures infected and treated with NGF or NT-3. The results showed that NGF, but not NT-3, caused an increase in the quantity of P protein and an accumulation of protein in neuronal bodies, revealing changes in transport to the neuritic processes.
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