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Updated: Jun 24, 2026

A Rat Model of Compound Acne

A Rat Model of Compound Acne

Published on: November 1, 2024

Hidradenitis suppurativa.

M G Buimer¹, T Wobbes, J H G Klinkenbijl

¹Department of Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. m.buimer@chir.umcn.nl

The British Journal of Surgery

|March 14, 2009

Summary

Hidradenitis suppurativa, also known as acne inversa, is an inflammatory skin condition. Smoking is a key factor, and treatment requires individualized medical or surgical approaches, including smoking cessation.

Area of Science:

Dermatology
Pathogenesis of skin diseases

Background:

Hidradenitis suppurativa (HS) is a chronic, recurrent, suppurative skin disease.
Optimal medical or surgical treatments for HS are not well-established.
This review covers HS pathogenesis, treatment, and prognosis.

Purpose of the Study:

To review the current understanding of hidradenitis suppurativa.
To discuss the pathogenesis, treatment, and prognosis of HS.
To highlight the role of smoking and individualized treatment strategies.

Main Methods:

Literature search conducted on PubMed and Medline.
MeSH terms used: 'hidradenitis suppurativa' and 'acne inversa'.
Article selection based on peer review, journal relevance, and English language.

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Main Results:

Histological findings suggest HS is an inflammatory disease originating from the hair follicle.
Smoking is identified as a significant triggering factor for HS.
Treatment requires individualization based on disease severity and location.

Conclusions:

The term 'acne inversa' is preferred by some experts due to the inflammatory nature of the disease.
Complete smoking cessation is crucial for managing hidradenitis suppurativa.
While medications may alleviate early symptoms, radical surgery might be necessary for long-term control and prevention of recurrence.