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A mechanism of efficient G6PD inhibition by a molecular clip

Michael Kirsch1, Peter Talbiersky, Jolanta Polkowska

  • 1Institut für Physiologische Chemie, Iniversitätsklinikum Essen, Hufelandstrasse 55, 45122 Essen, Germany.

Angewandte Chemie (International Ed. in English)
|March 14, 2009
PubMed

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Enzyme Inhibition

Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.