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Updated: Jun 24, 2026

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis
Published on: September 6, 2019
Efficient and systematic synthesis of a small glycoconjugate library having human complex type oligosaccharides
Takefumi Murase1, Takashi Tsuji, Yasuhiro Kajihara
1International Graduate School of Arts and Sciences, Yokohama City University, Yokohama, Kanagawa, Japan.
Abstract:
To prepare a small library of homogeneous glycoconjugates with varying oligosaccharide structures, a combinatorial strategy was employed. The target glycopeptide was divided into two peptide segments (A and B) and both were prepared by solid phase peptide synthesis. These peptides, which can be coupled by native chemical ligation through an amide bond, were subsequently coupled to two kinds of human complex type oligosaccharides. This process systematically afforded the desired glycoconjugate library.
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