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Updated: Jun 24, 2026
05:44
Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm
Published on: March 1, 2019
[Sperm acrosin activity helps predict IVF-ET outcome]
Xin-Jie Chen1, Xiao-Lin Long, Xiao-Fang Sun
1Guangzhou Key Laboratory of Reproduction and Genetics, The Third Affiliated Hospital of Guangzhou Medical College, Guangzhou, Guangdong 510150, China.
Zhonghua Nan Ke Xue = National Journal of Andrology
|March 18, 2009
Summary
Sperm acrosin activity significantly impacts in vitro fertilization success. Higher acrosin activity correlates with better semen parameters and improved IVF-ET outcomes, including fertilization and clinical pregnancy rates.
Area of Science:
- Reproductive Biology
- Andrology
- In Vitro Fertilization
Context:
- Sperm function is crucial for successful fertilization.
- Acrosin, a key enzyme, plays a vital role in sperm penetration of the egg.
- Assessing sperm acrosin activity can provide insights into male fertility.
Purpose:
- To evaluate the association between sperm acrosin activity and outcomes of in vitro fertilization with embryo transfer (IVF-ET).
- To determine if sperm acrosin activity can predict the success of IVF-ET procedures.
Summary:
- A study of 909 infertile men analyzed sperm parameters and acrosin activity.
- Lower acrosin activity was linked to poorer sperm morphology, motility, and concentration.
- Normal acrosin activity was associated with significantly higher fertilization, implantation, and clinical pregnancy rates in IVF-ET.
Impact:
- Sperm acrosin activity is a valuable biomarker for predicting male fertilizing capacity.
- This finding can help optimize patient selection and improve IVF-ET success rates.
- Understanding acrosin's role enhances diagnostic and therapeutic strategies in infertility.
Related Concept Videos
01:24In Vitro Fertilization
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
01:38Fertilization
During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
01:41Spermatogenesis
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...
01:23Infertility in Males
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