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[Experimental approach to nutritional problems in chronic renal insufficiency]
C Kleinknecht1, D Laouari, M Burtin
1INSERM U. 192, Hôpital Necker, Enfants Malades, Paris.
Annales De Pediatrie
|June 1, 1991
Summary
Experimental chronic renal failure (CRF) in rats mimics human pediatric CRF, showing altered eating behaviors and optimal protein intake near minimum recommendations. Adjusting protein and water intake significantly impacts renal function and growth.
Area of Science:
- Nephrology
- Animal Models
- Nutritional Science
Context:
- Experimental chronic renal failure (CRF) models offer insights into naturally occurring pediatric CRF.
- CRF models demonstrate altered eating behaviors, including reduced appetite for sweets and preference for high-protein foods.
Purpose:
- To investigate the impact of dietary interventions on growth and renal lesion progression in experimental CRF.
- To compare the effects of protein restriction, ketoanalogs, and high-sucrose diets in CRF models.
Summary:
- Optimal protein intake in CRF models approximates minimum recommendations for growth, with excessive intake proving detrimental.
- A 50% protein reduction with essential amino acids supported normal growth and slowed renal lesion progression.
- High sucrose diets were poorly tolerated, leading to fructose intolerance and reduced liver energy stores.
Impact:
- Findings provide a basis for dietary management strategies in pediatric chronic renal failure.
- Highlights the critical role of water intake and protein modulation in managing CRF.
- Suggests caution with high-sucrose diets in renal impairment.