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Cod Skin Collagen Peptides Alleviate Ulcerative Colitis by Regulating Gut Microbiota to Inhibit NLRP3 Inflammasome
Longyi Piao1, Jiaqi Huo1, Yanru Dong1
1Key Laboratory of Cellular Function and Pharmacology of Jilin Province Yanbian University Yanji China.
Food Science & Nutrition
|August 9, 2026
Summary
Cod skin collagen oligopeptide powder (CP) effectively treats ulcerative colitis (UC) in mice by modulating gut microbiota. CP reduces inflammation and promotes colon healing, offering a novel therapeutic approach for inflammatory bowel disease.
Area of Science:
- Gastroenterology
- Immunology
- Microbiology
Background:
- Enteral nutrition is crucial for ulcerative colitis (UC) management.
- Collagen peptides may enhance immune function and intestinal barrier repair.
- The mechanism of cod skin collagen oligopeptides (CP) in modulating gut microbiota for UC treatment is unclear.
Purpose of the Study:
- To investigate the mechanism by which CP affects gut microbiota to treat UC.
- To evaluate CP's therapeutic effects in a mouse model of DSS-induced UC.
Main Methods:
- 16S rRNA sequencing to analyze gut microbiota composition.
- Fecal microbiota transplantation (FMT) to confirm CP's microbiota-dependent effects.
- Histological, immunohistochemical, and ELISA analyses to assess colon damage, inflammation, and fibrosis.
Main Results:
- CP significantly altered gut microbiota diversity and organization in UC mice.
- FMT confirmed CP's role in alleviating UC through microbiota modulation.
- CP improved body weight, colon length, and histopathology, reduced inflammatory markers (NLRP3, IL-1β), and inhibited fibrosis.
- CP upregulated ZO-1 and Occludin while downregulating fibrosis-associated proteins.
Conclusions:
- CP treatment alleviates DSS-induced colitis in mice by modulating the gut microbiota.
- CP suppresses NLRP3 inflammasome activation, promoting colonic healing and reducing inflammation.
- CP demonstrates potential as a therapeutic agent for UC by targeting gut microbiota and inflammation.
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