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Updated: Jun 24, 2026
14:14
Simultaneous Quantification of T-Cell Receptor Excision Circles (TRECs) and K-Deleting Recombination Excision Circles (KRECs) by Real-time PCR
Published on: December 6, 2014
[Assessing the number of TB cases using the capture-recapture method with two data sources]
1Universitatea de Medicină şi Farmacie "Gr.T. Popa" Iaşi, Facultatea de Medicină, Clinica de Pneumologie.
Summary
The capture-recapture method estimated 1,348 tuberculosis (TB) cases in Iaşi County, indicating notification completeness of 84%. This method improves TB case assessment accuracy.
Area of Science:
- Epidemiology
- Public Health
- Infectious Diseases
Background:
- Accurate tuberculosis (TB) case ascertainment is crucial for effective control programs.
- Existing surveillance systems may underestimate the true TB burden.
- The capture-recapture method offers a robust approach to estimate undercounted cases.
Purpose of the Study:
- To accurately assess the total number of tuberculosis cases in Iaşi County.
- To evaluate the completeness of TB case notifications using the capture-recapture method.
Main Methods:
- Utilized a capture-recapture methodology employing two data sources: the Registry of Tuberculosis and laboratory records.
- Included TB patients diagnosed and microbiologically examined in Iaşi County.
- Analyzed data from 1,134 notifications and 763 laboratory-confirmed cases.
Main Results:
- The capture-recapture analysis estimated a total of 1,348 TB patients (95% CI: 1,320-1,375).
- The overlap between the two data sources was 51%.
- Notification completeness was estimated at 84.1% (95% CI: 82.5-85.9%), while laboratory data completeness was 56.6% (95% CI: 55.5-57.8%).
Conclusions:
- The capture-recapture method provides a more accurate estimate of the TB burden in Iaşi County.
- Notification completeness is approximately 84%, aligning with World Health Organization (WHO) estimations.
- This study highlights the underestimation of TB cases by single data sources.
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