[The influence of the dihydroxamic compounds on the rat lung]

The role of the dihydroxamic compounds in the human and animal organism are little known. This is the reason they the experiment studies the effect of these compounds on the rat lung. 3 lots of Wistar adult male rats were used. The first lot was the witness lot and did not receive any substance. The second lot received Dihydroxamic adipoil acid, 0.5 mg/kg weight/ day, intraperitoneal administration in a unique daily dose, for 3 weeks. The third lot received Dihydroxamic terephtaloyl acid, 0.5 mg/kg weight/day, intraperitoneal administration in a unique daily dose. After 14 and 21 days the animals of each lot were euthanised by sectioning carotid arteries. The authors collected the lungs, prepared the histological sections, stained in HE and Szekely. The witness lot presented normal rat lung structure. After 2 and 3 weeks of treatment, the second lot presented distended blood vessels. After 2 and 3 weeks of treatment, the third lot presented very severe alterations of the lung tissue at all levels.