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Updated: Jun 24, 2026

Purification of the Dendritic Filopodia-rich Fraction
Published on: May 2, 2019
Presenilin 1 modifies lipid raft composition of neuronal membranes
Gunter P Eckert1, Walter E Müller
1Department of Pharmacology, ZAFES, Campus Riedberg, Biocenter Niederursel, University of Frankfurt, Frankfurt, Germany. G.P.Eckert@em.uni-frankfurt.de
Abstract:
Protein-lipid interactions in the nervous system may provide insight into the causes of neurological disorders. In this study, we elucidated if expression of human presenilin 1 (PS1) in a mouse model changes the physico-chemical properties of brain membranes. PS1 is a multifunctional transmembrane protein and part of the gamma-secretase complex. This complex is critical for the production of the Alzheimer related amyloid beta peptide. Brain membranes isolated from mice expressing a human wild-type PS1 transgene are less fluid and contain higher cholesterol and sphingomyelin levels. Moreover, our data reveal significant changes in membrane micro-domains and indicate that PS1 induces the formation of lipid rafts.
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