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Related Concept Videos

Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives01:22

Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives

Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This makes...
Drugs Affecting GI Tract Motility: Other Laxatives01:20

Drugs Affecting GI Tract Motility: Other Laxatives

Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Cellulose and Pectic Polysaccharides01:15

Cellulose and Pectic Polysaccharides

Every plant cell has a cell wall that protects the cell, provides structural support, and gives the cell shape. Cellulose, the main structural component of the plant cell wall, makes up over 30% of plant matter. It is the most abundant organic compound on earth.  Cellulose is an unbranched polysaccharide composed of linear chains of glucose molecules linked by β (1→4) glycosidic bonds.
As a cell matures, its cell wall specializes according to its type. For example, the parenchyma cells of...
Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents01:20

Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents

Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...

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Related Experiment Videos

[Efficacy of cellulose on functional constipation].

Bao-hua Liu1, Xin-qing Yang, Dong-lin Ren

  • 1Research Institute of Surgery, Daping Hospital, Chongqing 400042, China. LBH57268@163.com

Zhonghua Wei Chang Wai Ke Za Zhi = Chinese Journal of Gastrointestinal Surgery
|March 20, 2009
PubMed
Summary
This summary is machine-generated.

Cellulose effectively treats functional constipation by improving defecation frequency and stool consistency. This clinical trial found cellulose to be a safe and well-tolerated treatment option for chronic constipation.

Related Experiment Videos

Area of Science:

  • Gastroenterology
  • Clinical Pharmacology
  • Dietary Fiber Research

Background:

  • Functional constipation is a prevalent gastrointestinal disorder.
  • Dietary fiber, such as cellulose, is a common therapeutic approach.
  • Evidence for cellulose's efficacy in functional constipation requires further clinical validation.

Purpose of the Study:

  • To evaluate the clinical effectiveness of cellulose in patients with functional constipation.
  • To assess the safety profile of cellulose treatment in this patient population.

Main Methods:

  • A prospective, self-controlled, multicenter clinical trial was conducted.
  • 240 patients diagnosed with functional constipation (Rome III criteria) participated.
  • Treatment duration was two weeks, with symptom and stool character evaluation.

Main Results:

  • Significant improvements in defecation frequency and stool consistency were observed.
  • High total efficacy rates were reported: 82.1% at day 7 and 90.7% at day 14.
  • No adverse reactions were reported, with satisfactory rates of 83.8% for both doctors and patients.

Conclusions:

  • Cellulose demonstrates significant clinical efficacy in managing functional constipation.
  • Cellulose is a safe and well-tolerated treatment for chronic functional constipation.
  • The study supports the use of cellulose as a therapeutic agent for constipation.