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Related Experiment Video

Updated: Jun 24, 2026

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
06:32

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Published on: January 9, 2019

Array-based genomics in glioma research.

Ahmed Idbaih1, Emmanuelle Crinière, Keith L Ligon

  • 1INSERM, Unité 711, Paris, France. ahmed.idbaih@gmail.com

Brain Pathology (Zurich, Switzerland)
|March 21, 2009
PubMed
Summary
This summary is machine-generated.

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Genomic arrays offer a reliable and cost-effective method for identifying glioma biomarkers. These advanced techniques simplify the detection of known and new genomic markers, improving glioma patient management.

Area of Science:

  • Neuro-oncology
  • Genomics
  • Molecular Diagnostics

Background:

  • Gliomas have known biomarkers identified through various complex techniques.
  • Previous methods like karyotype and FISH have limitations in clinical application.
  • Genomic arrays present a more feasible and reliable alternative for glioma biomarker discovery.

Purpose of the Study:

  • To review the utility and reliability of genomic arrays for glioma characterization.
  • To highlight the effectiveness of genomic arrays in identifying known and novel glioma biomarkers.
  • To advocate for the clinical implementation of genomic arrays in glioma diagnostics.

Main Methods:

  • Review of studies utilizing genomic arrays (aCGH and SNP arrays) for glioma genomic characterization.

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Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
09:40

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

Published on: October 4, 2019

Related Experiment Videos

Last Updated: Jun 24, 2026

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
06:32

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Published on: January 9, 2019

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
09:40

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

Published on: October 4, 2019

  • Assessment of the feasibility and reliability of genomic arrays in clinical settings.
  • Analysis of identified genomic biomarkers and signatures in gliomas.

    • Main Results:

    • Genomic arrays reliably identify well-established glioma biomarkers.
    • These arrays detect numerous novel cryptic genomic markers with potential clinical significance.
    • Recurrent genomic signatures in gliomas have been consistently reported across multiple studies using genomic arrays.

    Conclusions:

    • Genomic arrays are simple, cost-effective, and reliable tools for glioma genomic profiling.
    • Their implementation in molecular diagnostic laboratories is encouraged for improved glioma patient management.
    • Genomic arrays enhance the understanding and clinical application of glioma biomarkers.