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Updated: Jun 24, 2026
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Nevus spilus with synchronous melanomas: case report and literature review
Ari-Nareg Meguerditchian1, Richard T Cheney, John M Kane
1Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. ari-nareg.meguerditchian@roswellpark.org
Background:
Nevus spilus is a rare, acquired, and often large cutaneous lesion consisting of a light brown background macule containing varying numbers of small darker macular or papular areas.
Objective:
Nevus spilus may contain dysplastic melanocytic elements, and there are also reports of melanoma arising from nevus spilus. However, the absolute risk for malignant transformation is not well defined.
Conclusion:
We discuss a case of synchronous melanomas arising from a nevus spilus and potential management recommendations based on a review of the pertinent literature.
