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Related Concept Videos

Irritable Bowel Syndrome01:23

Irritable Bowel Syndrome

DefinitionIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent combinations of abdominal pain, bloating, diarrhea, or constipation.Pathophysiology of irritable bowel syndromeIts pathophysiology is multifactorial, involving disturbances in motility, sensory processing, microbial balance, barrier integrity, and gut–brain communication. These mechanisms interact to produce symptoms that vary across IBS subtypes.Altered Motility PatternsDisordered...
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...

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A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium
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Published on: May 31, 2024

Postinfectious irritable bowel syndrome.

Giovanni Barbara1, Cesare Cremon, Francesca Pallotti

  • 1Department of Internal Medicine and Gastroenterology and CRBA, University of Bologna, Bologna, Italy. giovanni.barbara@unibo.it

Journal of Pediatric Gastroenterology and Nutrition
|March 21, 2009
PubMed
Summary
This summary is machine-generated.

Postinfectious (PI) IBS, a common outcome of gastroenteritis, involves abdominal pain and diarrhea. Risk factors and mucosal changes are identified, but specific treatments require further study.

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Area of Science:

  • Gastroenterology
  • Immunology
  • Microbiology

Background:

  • Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder with abdominal pain and altered bowel habits.
  • Postinfectious (PI) IBS is a recognized subtype developing after acute infectious gastroenteritis.
  • Pathogenic agents like bacteria, parasites, and viruses can trigger PI-IBS.

Purpose of the Study:

  • To review the evidence linking infectious gastroenteritis to IBS development.
  • To identify risk factors and mucosal abnormalities associated with PI-IBS.
  • To discuss the limited knowledge regarding PI-IBS prognosis and treatment.

Main Methods:

  • Literature review of studies on PI-IBS.
  • Analysis of risk factors for PI-IBS development.
  • Examination of reported mucosal abnormalities in PI-IBS patients.

Main Results:

  • Common symptoms include abdominal pain and diarrhea.
  • Risk factors include pathogen virulence, enteritis severity/duration, younger age, female sex, and psychological factors.
  • Mucosal changes involve increased permeability, lymphocytes, mast cells, and enteroendocrine cells.

Conclusions:

  • PI-IBS is a distinct entity following infectious gastroenteritis.
  • Mucosal immune activation and neuroendocrine changes may contribute to symptoms.
  • Further research is needed to establish prognosis and effective treatments for PI-IBS.