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Related Experiment Video

Updated: Jun 24, 2026

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Published on: September 7, 2017

Imaging angiogenesis.

Natalie Charnley¹, Stephanie Donaldson, Pat Price

¹University of Manchester, Wolfson Molecular Imaging Centre, Manchester, UK.

Methods in Molecular Biology (Clifton, N.J.)

|March 24, 2009

Summary

This summary is machine-generated.

Directly imaging tumor vasculature is crucial for evaluating anti-cancer drug effectiveness. Advanced imaging techniques assess tumor blood flow, permeability, and hypoxia to monitor treatment response.

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Published on: November 23, 2014

Area of Science:

Oncology
Medical Imaging
Pharmacology

Background:

Assessing anti-cancer drug efficacy requires direct visualization of tumor vasculature.
Tumor vasculature imaging relies on differential contrast agent penetration between tumor and normal tissues.
Tumor hypoxia assessment provides insights into vascular status.

Purpose of the Study:

To highlight the necessity of direct tumor vasculature imaging for treatment response assessment.
To define angiogenesis imaging in terms of perfusion and molecular imaging.
To outline available imaging modalities for evaluating tumor vasculature.

Main Methods:

Utilizing differences in vascular permeability for contrast agent penetration.
Measuring tumor perfusion.
Directly imaging molecules involved in angiogenesis.
Assessing tumor hypoxia.

Main Results:

Positron emission tomography (PET), dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), perfusion computed tomography (CT), and ultrasound (US) are key imaging techniques.
These methods enable the assessment of tumor perfusion, vascular permeability, and hypoxia.
Direct imaging of angiogenesis-related molecules is also feasible.

Conclusions:

Direct imaging of tumor vasculature is essential for evaluating responses to antiangiogenic and vascular disrupting agents.
A combination of imaging techniques provides comprehensive assessment of tumor vascular characteristics.
These imaging strategies are vital for personalized cancer therapy and drug development.