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Related Concept Videos

Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Rocky Mountain Spotted Fever01:26

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Myocarditis I: Introduction01:21

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Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
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Updated: Jun 24, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Histiocytic erythema multiforme.

Anita Sebastian1, Connor Patterson, Andrea L Zaenglein

  • 1Department of Pathology, Hahnemann University Hospital/Drexel College of Medicine, Philadelphia, PA, USA.

Journal of Cutaneous Pathology
|March 24, 2009
PubMed
Summary

This study reports a rare case of histiocytic erythema multiforme in a child. The condition presented with unusual CD68-positive immune cells, differing from typical lymphocytic infiltrates in erythema multiforme.

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Last Updated: Jun 24, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

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Published on: February 8, 2019

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
07:52

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma

Published on: January 9, 2019

Area of Science:

  • Dermatology
  • Immunohistochemistry
  • Histopathology

Background:

  • Erythema multiforme (EM) is an acute, immune-mediated condition characterized by specific histological findings.
  • Typical EM involves liquefactive degeneration, necrotic keratinocytes, and a lymphocytic infiltrate at the dermal-epidermal junction.
  • The etiology of recurrent EM is often undetermined.

Purpose of the Study:

  • To report a unique case of recurrent erythema multiforme major in a pediatric patient.
  • To describe unusual histological findings in a skin biopsy of erythema multiforme.
  • To investigate the immune cell infiltrate in a case of 'histiocytic' erythema multiforme.

Main Methods:

  • A skin biopsy was performed on a 10-year-old boy presenting with erythema multiforme major.
  • Histopathological examination of the biopsy was conducted.
  • Immunohistochemical staining was utilized, specifically focusing on CD68 expression.

Main Results:

  • The skin biopsy revealed histological features consistent with erythema multiforme.
  • However, the infiltrate was predominantly CD68-positive, unlike the typical lymphocytic infiltrate seen in EM.
  • These findings resembled those observed in cutaneous Kikuchi's disease.

Conclusions:

  • This case represents the first reported instance of 'histiocytic' erythema multiforme.
  • The presence of a CD68-positive infiltrate suggests a distinct immunopathological mechanism in this patient.
  • Further research is warranted to understand the implications of this histiocytic variant of erythema multiforme.