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Enterovirus infections in neonates

Marc Tebruegge1, Nigel Curtis

  • 1Department of Paediatrics, The University of Melbourne, Royal Children's Hospital Melbourne, Flemington Road, Parkville, VIC 3052, Australia.

Seminars in Fetal & Neonatal Medicine
|March 24, 2009
PubMed

Insights

Enterovirus infections are common in infants, causing severe illness and death, especially in newborns. This review covers epidemiology, clinical features, diagnostics, and treatments for neonatal enteroviral infections.

Area of Science:

  • Virology
  • Neonatal Medicine
  • Infectious Diseases

Background:

  • Enteroviruses are common human pathogens, frequently causing illness in neonates and infants.
  • Enteroviral infections in neonates present a wide spectrum of clinical severity, with significant morbidity and mortality, particularly with antenatal exposure.
  • Understanding these infections is crucial for timely diagnosis and management.

Purpose of the Study:

  • To provide a comprehensive overview of enterovirus infections specifically in the neonatal period.
  • To detail the epidemiology, clinical manifestations, and laboratory features of neonatal enterovirus infections.
  • To review current prophylactic and therapeutic interventions, including antiviral therapies.

Main Methods:

  • This study is a review of existing literature on enterovirus infections in neonates.
  • It synthesizes data on epidemiology, clinical presentation, diagnostic methods, and treatment strategies.
  • The review focuses on research relevant to the neonatal age group.

Main Results:

  • Enteroviruses are a significant cause of serious illness and mortality in newborns.
  • Clinical presentations range widely, and antenatal transmission increases risk.
  • Diagnostic investigations and available treatments are discussed in detail.

Conclusions:

  • Enterovirus infections pose a substantial threat to neonatal health, necessitating thorough understanding and management.
  • Early diagnosis and appropriate intervention are critical for improving outcomes in infected neonates.
  • Further research into effective prophylactic and therapeutic strategies is warranted.

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