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Related Concept Videos

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome01:23

Irritable Bowel Syndrome

DefinitionIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent combinations of abdominal pain, bloating, diarrhea, or constipation.Pathophysiology of irritable bowel syndromeIts pathophysiology is multifactorial, involving disturbances in motility, sensory processing, microbial balance, barrier integrity, and gut–brain communication. These mechanisms interact to produce symptoms that vary across IBS subtypes.Altered Motility PatternsDisordered...
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Irritable Bowel Syndrome III: Medical and Nursing Management01:30

Irritable Bowel Syndrome III: Medical and Nursing Management

Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

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Related Experiment Video

Updated: Jun 24, 2026

A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium
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[Irritable bowel syndrome: outcome aspects].

S Bruley des Varannes1

  • 1Institut des Maladies de l'Appareil Digestif, CHU Hôtel Dieu, 44093 Nantes cedex, France. stanislab.bruleydesvarannes@chu-nantes.fr

Gastroenterologie Clinique Et Biologique
|March 24, 2009
PubMed
Summary

Irritable bowel syndrome (IBS) is a chronic condition with fluctuating symptoms. While some patients recover within months, many experience long-term issues, with psychiatric factors significantly impacting the disease course.

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Area of Science:

  • Gastroenterology
  • Clinical Medicine
  • Psychiatry

Background:

  • Irritable bowel syndrome (IBS) is a chronic, relapsing gastrointestinal disorder.
  • Symptom severity and clinical characteristics in IBS patients frequently change over time.
  • Understanding the long-term progression and predictors of IBS is crucial for effective management.

Purpose of the Study:

  • To define broad progressive trends in irritable bowel syndrome.
  • To investigate short-term and long-term outcomes in IBS patients.
  • To identify potential predictors of IBS clinical course and prognosis.

Main Methods:

  • Longitudinal observation of IBS patients.
  • Analysis of symptom patterns over very short, medium (3 months), and long terms (several years).
  • Evaluation of clinical improvement at 3 months as a prognostic indicator.

Main Results:

  • Short-term symptom sequences are interrupted by remissions.
  • 20%-40% of patients show symptom recovery by 3 months; early improvement correlates with better 1-year prognosis.
  • 60%-70% of patients have persistent symptoms long-term, with high symptom turnover and overlap with dyspepsia.
  • Psychiatric comorbidities are highly significant in the IBS clinical course.

Conclusions:

  • Irritable bowel syndrome exhibits variable progression with frequent symptom changes.
  • While some patients experience recovery, a significant proportion face chronic symptoms and symptom overlap.
  • Psychiatric comorbidities play a critical role in the long-term management and prognosis of IBS.