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Correction of Presbyopia by Monocular Bi-Aspheric Ablation Profile
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Published on: September 20, 2024

Mitomycin-C in hyperopic photorefractive keratectomy.

Antonio Leccisotti1

  • 1Ophthalmic Surgery Unit, Casa di Cura Rugani, Siena, Italy. leccisotti@libero.it

Journal of Cataract and Refractive Surgery
|March 24, 2009
PubMed
Summary

Topical mitomycin-C (MMC) significantly reduced haze and improved visual outcomes after hyperopic photorefractive keratectomy (PRK). This treatment enhanced predictability and efficacy without adverse effects.

Area of Science:

  • Ophthalmology
  • Corneal Surgery
  • Refractive Surgery

Background:

  • Hyperopic photorefractive keratectomy (PRK) can be associated with haze formation and refractive unpredictability.
  • Mitomycin-C (MMC) is an antifibrotic agent with potential to mitigate these complications.

Purpose of the Study:

  • To evaluate the efficacy and safety of topical mitomycin-C (MMC) application following hyperopic photorefractive keratectomy (PRK).

Main Methods:

  • A prospective study involving 179 eyes undergoing hyperopic PRK.
  • Application of 0.2 mg/mL MMC or balanced salt solution (control) to the stroma for 45 seconds post-PRK.
  • Postoperative management included fluorometholone 0.1% eyedrops for 4 months.

Main Results:

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  • The MMC group showed significantly reduced mean spherical equivalent and defocus equivalent at 18 months (P<.05).
  • Improved uncorrected visual acuity (UCVA) was observed in the MMC group (94% > 20/40 vs. 80% in control, P<.05).
  • Significantly less haze formation was noted in the MMC group (P<.05) with no endothelial damage.

Conclusions:

  • Topical MMC effectively prevents haze formation after hyperopic PRK.
  • MMC improves refractive predictability and visual outcomes.
  • The treatment demonstrated a favorable safety profile with no observed adverse effects.