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Related Concept Videos

Human Virome01:26

Human Virome

The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible only with...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Investigation of Disease Outbreaks01:23

Investigation of Disease Outbreaks

Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...
Genetic Variation01:25

Genetic Variation

Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles, which...
Principles of Disease Surveillance01:26

Principles of Disease Surveillance

Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

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Cost-effective Method for Microbial Source Tracking Using Specific Human and Animal Viruses
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Published on: December 3, 2011

Planning the human variome project: the Spain report.

Jim Kaput1, Richard G H Cotton, Lauren Hardman

  • 1Division of Personalised Nutrition and Medicine, FDA/National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. James.kaput@fda.hhs.gov

Human Mutation
|March 24, 2009
PubMed
Summary

Understanding human genetic variation is key to personalized medicine. The Human Variome Project aims to systematically collect mutation data to advance this goal.

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Last Updated: Jun 24, 2026

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Area of Science:

  • Genomics and Bioinformatics
  • Human Genetics
  • Personalized Medicine

Background:

  • Despite advances like the Human Genome Project, current knowledge is insufficient for comprehensive biomedical research.
  • Characterizing human genetic variation is essential for understanding phenotypic variability and heritability.
  • Existing data suggests a need for more systematic efforts to map genetic diversity.

Framework:

  • The Human Variome Project (HVP) was proposed to systematically collect disease-causing mutations.
  • Establish a cyber infrastructure to link locus-specific databases (LSDBs).
  • Facilitate a unified approach to cataloging human genetic variation.

Implementation:

  • Discussions and recommendations from the 2008 HVP planning meeting in Spain.
  • Focus on developing the necessary infrastructure for data collection and sharing.
  • Outline strategies for systematic mutation data acquisition.

Implications:

  • Crucial for the development of personalized nutrition and medicine.
  • Enhances understanding of genotype-environment interactions.
  • Accelerates research into the genetic basis of human diseases.