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Related Concept Videos

Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
Fats as Energy Storage Molecules01:06

Fats as Energy Storage Molecules

Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis directly...

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Related Experiment Video

Updated: Jun 24, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
08:34

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

Dead adipocytes and metabolic dysfunction: recent progress.

Michael West1

  • 1Department of Medicine, Division of Endocrinology and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA. mwest12@jhmi.edu

Current Opinion in Endocrinology, Diabetes, and Obesity
|March 25, 2009
PubMed
Summary
This summary is machine-generated.

Crown-like structures (CLSs) form around dead adipocytes and are linked to metabolic diseases. Research is advancing our understanding of CLS biology and their role in obesity and cardiovascular conditions.

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Last Updated: Jun 24, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
08:34

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Published on: June 3, 2016

Exploring Adipose Tissue Structure by Methylsalicylate Clearing and 3D Imaging
10:10

Exploring Adipose Tissue Structure by Methylsalicylate Clearing and 3D Imaging

Published on: August 19, 2020

Area of Science:

  • Adipose tissue biology
  • Immunology
  • Metabolic disease research

Background:

  • Crown-like structures (CLSs) involve dead adipocytes and adipose tissue macrophages (ATMs).
  • CLSs are implicated in obesity, insulin resistance, diabetes, atherosclerosis, and cardiovascular disease.

Purpose of the Study:

  • To review recent findings on CLSs and dead adipocytes.
  • To project future research directions in this field.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of ATM phenotypes in mice and humans.
  • Quantification of fat cell aging and turnover in humans.
  • Establishment of correlations between CLSs and cardiovascular disease.

Main Results:

  • Differences in ATM phenotypes (M1 vs. M2) between mice and humans observed.
  • Correlation established between human CLSs and early cardiovascular disease.
  • Osteopontin identified as a macrophage chemoattractant to dead adipocytes, alongside MCP-1 and CCR2.

Conclusions:

  • Recent research provides updates on dead adipocyte and CLS biology.
  • These findings have clinical implications for metabolic dysfunction.