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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...

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Related Experiment Video

Updated: Jun 24, 2026

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia
06:33

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia

Published on: November 10, 2023

Bone marrow microenvironment and tumor progression.

Christophe F Chantrain1, Olivier Feron, Etienne Marbaix

  • 1Division of Hematology-Oncology, Department of Pediatrics, Universite Catholique de Louvain, Brussels, Belgium.

Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society
|March 25, 2009
PubMed
Summary

The bone marrow microenvironment supports cancer cell growth and survival by recruiting tumor cells and promoting their proliferation. This intricate relationship impacts cancer progression and therapeutic outcomes, highlighting the need for further research.

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Last Updated: Jun 24, 2026

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia
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Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia

Published on: November 10, 2023

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
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Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

Modeling Chemotherapy Resistant Leukemia In Vitro
08:41

Modeling Chemotherapy Resistant Leukemia In Vitro

Published on: February 9, 2016

Area of Science:

  • Oncology
  • Cancer Biology
  • Bone Biology

Background:

  • The bone marrow provides a unique microenvironment for cancer cells, influencing their proliferation, survival, and interaction with the host.
  • Tumor cells disrupt bone homeostasis, releasing growth factors that fuel cancer progression.
  • Bone marrow-derived cells play critical roles in tumor progression, inflammation, and neovascularization.

Purpose of the Study:

  • To review the reciprocal relationship between the bone marrow microenvironment and tumor cells.
  • To discuss the impact of this relationship on cancer therapy.
  • To highlight the importance of understanding bone marrow's role in cancer progression.

Main Methods:

  • Literature review of existing research on the bone marrow microenvironment and cancer.
  • Analysis of the mechanisms by which bone marrow influences tumor cells.
  • Discussion of the implications for cancer treatment strategies.

Main Results:

  • The bone marrow actively recruits circulating tumor cells, offering a sanctuary for proliferation and survival.
  • Tumor cells recruit bone marrow-derived precursor cells, contributing to inflammation and tumor vasculature.
  • Bone marrow-derived cells can establish niches in distant organs, attracting circulating tumor cells.

Conclusions:

  • The bone marrow microenvironment significantly contributes to cancer progression through multiple mechanisms.
  • Cancer therapies can impact the bone marrow microenvironment, potentially altering their own efficacy.
  • Further investigation into the bone marrow-cancer crosstalk is crucial for developing effective cancer treatments.