Related Experiment Video
Updated: Jun 24, 2026

A Modified In vitro Invasion Assay to Determine the Potential Role of Hormones, Cytokines and/or Growth Factors in Mediating Cancer Cell Invasion
Published on: April 24, 2015
Abnormal growth factor/cytokine network in gastric cancer
1Hiroshima University, Hiroshima Cancer Seminar Foundation, Naka-ku, Hiroshima, Japan. etahara@h-gan.com
Abstract:
Gastric cancer cells express a broad spectrum of the growth factor/cytokine receptor systems that organize the complex interaction between cancer cells and stromal cells in tumor microenvironment, which confers cell growth, apoptosis, morphogenesis, angiogenesis, progression and metastasis. However, these abnormal growth factor/cytokine networks differ in the two histological types of gastric cancer. Importantly, activation of nuclear factor-kB pathway by Helicobacter pylori infection may act as a key player for induction of growth factor/cytokine networks in gastritis and pathogenesis of gastric cancer. Better understanding of these events will no doubt provide new approaches for biomarkers of diagnosis and effective therapeutic targeting of gastric cancer.
Related Concept Videos
Mitogens and the Cell Cycle
Role of Hematopoietic Growth Factors
Thrombopoietin (TPO), mainly released by the liver,...
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Abnormal Proliferation
Abnormal Proliferation
The Tumor Microenvironment