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Updated: Jun 24, 2026

Using the Chicken Chorioallantoic Membrane In Vivo Model to Study Gynecological and Urological Cancers
Published on: January 28, 2020
Cervical signet-ring cell carcinoma presenting as a synchronous primary carcinoma with uterine adenocarcinoma
William J Lowery1, Megan J Difurio, Michael J Sundborg
1Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Fort Sam Houston, TX 78234, USA.
Background:
Synchronous primary gynecologic tumors are relatively uncommon with the diagnosis often made following initial surgery.
Case:
A multiparous female in her 50s with postmenopausal bleeding was referred to our institution with a biopsy-proven diagnosis of endometrial cancer. Preoperative physical exam revealed a suspicious cervical lesion and upon biopsy she was found to have a signet-ring cell carcinoma of the cervix. Secondary to morbid obesity, the patient was not a candidate for a radical hysterectomy and was treated with curative radiation for stage IB 1 cervical carcinoma and clinical stage I endometrial carcinoma.
Conclusion:
Cervical signet-ring cell carcinoma is an extremely rare pathologic diagnosis. The preoperative discovery of synchronous primary gynecological tumors necessitates individualized planning and treatment.
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