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Association between ADAM33 polymorphisms and asthma in a Thai population
Torpong Thongngarm1, Aree Jameekornrak, Chanin Limwongse
1Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. sittn@mahidol.ac.th
Asian Pacific Journal of Allergy and Immunology
|March 26, 2009
Summary
This study found that variations in the ADAM33 gene are linked to asthma in the Thai population. Specific gene markers were associated with asthma susceptibility and severity.
Area of Science:
- Genetics
- Pulmonology
- Human Population Studies
Background:
- ADAM33 (A Disintegrin And Metalloprotease 33) is a known asthma susceptibility gene in various populations.
- Limited data exists on ADAM33 gene variations within the Thai population.
Purpose of the Study:
- To investigate the association between ADAM33 gene polymorphisms and asthma in Thai individuals.
- To explore potential links between specific ADAM33 variants and asthma severity.
Main Methods:
- Genotyping of 8 single nucleotide polymorphisms (SNPs) in the 3' region of the ADAM33 gene.
- Comparative analysis of allele frequencies between 200 asthmatic patients and 100 healthy controls.
- Statistical analysis including single-marker and haplotype association tests.
Main Results:
- Significant differences in allele frequencies for SNPs rs528557/S2, rs598418, and rs44707/ST+4 were observed between asthmatics and controls.
- SNP rs528557/S2 showed association with low asthma severity, while rs598418 and rs44707/ST+4 were linked to high severity.
- A significant association with asthma was identified for the two-SNP haplotype rs528557/S2 and rs598418.
Conclusions:
- ADAM33 gene polymorphisms are associated with asthma susceptibility in the Thai population.
- Specific ADAM33 variants may correlate with different asthma severity levels.
- This research provides crucial genetic insights into asthma in Thailand.
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