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Ewing's sarcoma/peripheral primitive neuroectodermal tumor (ES/PNET) differentiation in endometrial serous carcinomas
M Ruhul Quddus1, Lanita Rashid, C James Sung
1Department of Pathology & Laboratory Medicine, Women & Infants Hospital and The Warren Alpert Medical School of Brown University, Providence, Rhode Island 02905, USA. mquddus@wihri.org
Reproductive Sciences (Thousand Oaks, Calif.)
|March 26, 2009
Summary
Ewing's sarcoma/peripheral neuroectodermal tumor differentiation was found in 7% of uterine serous carcinomas and 12.5% of high-grade endometrioid endometrial carcinomas. This finding is significant due to the poorer prognosis associated with this differentiation.
Area of Science:
- Gynecologic Pathology
- Oncology
- Molecular Diagnostics
Background:
- The association between Ewing's sarcoma/peripheral neuroectodermal tumor (ES/PNET) and endometrioid endometrial carcinoma is a recent finding.
- ES/PNET differentiation has been identified in uterine serous carcinomas (USC).
Purpose of the Study:
- To evaluate the frequency of ES/PNET differentiation in both USC and endometrioid endometrial carcinomas.
- To assess the clinical significance of ES/PNET differentiation in endometrial cancers.
Main Methods:
- Retrieved 70 cases of USC and 56 FIGO grade 3 endometrioid carcinomas.
- Performed immunohistochemical staining using CD99 antibodies.
- Evaluated staining patterns: perinuclear dot-like and/or membranous staining was considered positive.
Main Results:
- ES/PNET differentiation was observed in 7% of USC cases.
- ES/PNET differentiation was detected in 12.5% of FIGO grade 3 endometrioid endometrial carcinomas.
- The presence of ES/PNET differentiation was linked to a worse prognosis.
Conclusions:
- ES/PNET differentiation occurs in a subset of high-grade endometrial carcinomas, including USC and endometrioid types.
- A high index of suspicion for ES/PNET differentiation is warranted in high-grade USC due to its association with a poorer prognosis.
- Further investigation into the clinical implications of ES/PNET differentiation in endometrial cancer is recommended.