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Photoresponsive tandem zinc finger peptide
Akiko Nomura1, Akimitsu Okamoto
1The Institute of Physical and Chemical Research, Wako, Saitama, 351-0198, Japan.
Abstract:
A photoresponsive tandem zinc finger peptide has been synthesized by attaching an azobenzene unit at its N-terminus resulting in a conjugate that retained a high binding ability toward the target DNA sequence, whereas it showed a significant decrease in DNA-binding ability after photoisomerization by UV irradiation to switch off the inhibition function from the DNA-binding protein.
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