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[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Aromatic trifluoromethylation catalytic in copper
Masahiro Oishi1, Hideaki Kondo, Hideki Amii
1Department of Chemistry, Graduate School of Science, Kobe University, Kobe, 657-8501, Japan.
Chemical Communications (Cambridge, England)
|March 26, 2009
Summary
Copper(I)-diamine complexes catalyze trifluoromethylation of aryl iodides using trifluoromethylsilanes. This efficient cross-coupling reaction yields valuable trifluoromethylated aromatic compounds.
Area of Science:
- Organometallic Chemistry
- Catalysis
- Organic Synthesis
Background:
- Trifluoromethylated aromatic compounds are important in pharmaceuticals and materials science.
- Efficient methods for introducing the trifluoromethyl group are highly sought after.
Purpose of the Study:
- To develop a catalytic system for the trifluoromethylation of aryl iodides.
- To explore the use of copper(I)-diamine complexes in cross-coupling reactions.
Main Methods:
- Utilizing copper(I) halides (CuX, where X = Cl, Br, I) as catalysts.
- Employing 1,10-phenanthroline (phen) as a ligand.
- Reacting aryl iodides with trifluoromethylsilanes under optimized conditions.
Main Results:
- Cu(I)-diamine complexes effectively catalyzed the trifluoromethylation of aryl iodides.
- The cross-coupling reactions proceeded smoothly, affording trifluoromethylated aromatics.
- Good yields of the desired products were obtained.
Conclusions:
- Copper(I)-diamine complexes are efficient catalysts for the trifluoromethylation of aryl iodides.
- This method provides a reliable route to synthesize trifluoromethylated aromatic compounds.
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