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A facile sequentially-activatable fluorescent probe for fast imaging of the superoxide anion in ulcerative colitis
Yanli Ning1, Zhenhong Wu1, Ziwei Zhang1
1Anhui Provincial Key Laboratory of Biomedical Materials and Chemical Measurement, Laboratory of Functionalized Molecular Solids, Ministry of Education, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241002, China. daixiaomei@mail.ahnu.edu.cn.
Abstract:
Herein, a sequentially-activatable fluorescent probe, PT-3F, is engineered for fast fluorescence imaging of superoxide anion (O2˙-) under alkaline conditions. The synthesized probe displays high selectivity, minimal background interference and rapid response to O2˙-, enabling in vivo fluorescence imaging of O2˙- in PC-12 cells and colons of mice with ulcerative colitis (UC).
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