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Related Experiment Video

Updated: Jan 13, 2026

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging
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NIR-II Polymer Dots for Real-Time Navigating Hepatic Resection and Hepatic Ischemia-Reperfusion Injury.

Zhen Shi1, Xiuyun Zhang1, Junyong Sun1

  • 1Anhui Provincial Key Laboratory of Biomedical Materials and Chemical Measurement, Laboratory of Functionalized Molecular Solids, Ministry of Education, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241002, P. R. China.

ACS Applied Bio Materials
|January 12, 2026
PubMed
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This study introduces novel polymer dots (Pdots) for real-time liver disease monitoring. These fluorescent probes enable precise intraoperative guidance for liver surgery and hemodynamic observation during liver injury.

Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Nanotechnology

Background:

  • Real-time monitoring of hepatic diseases is crucial for clinical outcomes.
  • Current fluorescent probes face challenges in preoperative visualization and intraoperative margin delineation.
  • Developing advanced probes is essential for improving hepatic disease management.

Purpose of the Study:

  • To develop a persistently luminescent NIR-II fluorescent probe for real-time intraoperative visualization of liver status.
  • To guide hepatic resection and observe hemodynamic changes during hepatic ischemia-reperfusion.
  • To advance liver-targeted polymer dot (Pdot)-based probes for clinical applications.

Main Methods:

  • Synthesized DPTQ08-IDT polymer dots (Pdots) emitting at 1050 nm in the NIR-II region.
Keywords:
NIR-II fluorescent probefluorescence imagingischemia–reperfusion injuryliver imagingpolymer dots

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  • Coassembled Pdots with folic acid (FA) for targeted binding to folate receptor alpha (FRα).
  • Utilized NIR-II fluorescence imaging for intraoperative guidance and hemodynamic observation.

    • Main Results:

    • The DPTQ08-IDT Pdots demonstrated specific binding to FRα overexpressed in hepatic tumor cells.
    • Achieved rapid hepatic accumulation and robust NIR-II fluorescence signals for precise intraoperative guidance.
    • Facilitated real-time observation of circulatory dynamics during hepatic ischemia-reperfusion.

    Conclusions:

    • The developed DPTQ08-IDT Pdots offer precise intraoperative guidance for liver resection.
    • The probe enables valuable insights into hepatic hemodynamics during ischemia-reperfusion.
    • This study highlights the potential of liver-targeted Pdot-based fluorescent probes in clinical liver disease management.