Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biochemical differences between human malignant and benign insulinoma tissues.

I Nakazawa, A Ohneda, K Mura

    The Tohoku Journal of Experimental Medicine
    |March 1, 1977
    PubMed
    Summary

    Malignant insulinoma tissues show higher eicosatrienoic acid levels in phospholipids compared to benign tumors. This lipid difference may play a role in malignant neoplastic growth.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Three TNFalpha single nucleotide polymorphisms in the Japanese population.

    Annals of human biology·2002
    Same author

    Fast MR imaging and ultrafast MR imaging of fetal central nervous system abnormalities.

    Osaka city medical journal·2002
    Same author

    Linkage disequilibrium and haplotype analysis among four novel single-nucleotide polymorphisms in the human leukemia inhibitory factor (LIF) gene.

    Journal of human genetics·2001
    Same author

    Antioxidative activity of volatile chemicals extracted from beer.

    Journal of agricultural and food chemistry·2001
    Same author

    Linkage disequilibrium and haplotype analysis among ten single-nucleotide polymorphisms of interleukin 11 identified by sequencing of the gene.

    Journal of human genetics·2001
    Same author

    Linkage disequilibrium and haplotype analysis among eight novel single-nucleotide polymorphisms in the human tissue-type plasminogen activator (t-PA) gene.

    Journal of human genetics·2001

    Area of Science:

    • Biochemistry
    • Oncology
    • Lipidomics

    Background:

    • Insulinomas are pancreatic neuroendocrine tumors.
    • Understanding lipid profiles in tumors can reveal growth mechanisms.

    Purpose of the Study:

    • To investigate lipid composition differences between malignant and benign insulinoma tissues.
    • To identify potential biomarkers for malignancy in insulinoma.

    Main Methods:

    • Lipid extraction from surgically obtained insulinoma tissues.
    • Separation of lipid fractions using thin-layer chromatography (TLC).
    • Analysis of fatty acid composition and content via gas-liquid chromatography (GLC).

    Main Results:

    • Significantly higher percentage of eicosatrienoic acid in phospholipid fractions of malignant insulinoma (9.82-3.32%) compared to benign insulinoma (2.89-2.57%).
    • Distinct fatty acid profiles were observed between malignant and benign insulinoma tissues.

    Conclusions:

    • Elevated eicosatrienoic acid in phospholipids is a key lipid difference distinguishing malignant from benign insulinoma.
    • These phospholipid alterations may contribute to the malignant growth of neoplastic tissue.

    Related Experiment Videos