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Kinevac (sincalide for injection)/Squibb Diagnostics
Summary
Sincalide, a synthetic cholecystokinin analog, offers rapid gallbladder contraction for diagnostic imaging. Its use in Kinevac speeds up intestinal transit, reducing radiation exposure during X-ray examinations.
Area of Science:
- Gastroenterology
- Radiology
- Pharmacology
Background:
- Sincalide is a synthetic analog of cholecystokinin (CCK) used intravenously.
- It induces prompt gallbladder contraction, differing from the gradual response to a fatty meal.
Purpose of the Study:
- To evaluate sincalide's role in diagnostic procedures.
- To assess its efficacy in accelerating small bowel transit time and aiding duodenal aspirate analysis.
- To explore its diagnostic value in biliary dyskinesia.
Main Methods:
- Intravenous administration of sincalide (Kinevac).
- Assessment of gallbladder contraction.
- Measurement of small bowel transit time.
- Duodenal aspiration for bile and pancreatic fluid analysis.
- Correlation with endoscopic manometry for sphincter of Oddi pressures.
Main Results:
- Sincalide causes rapid gallbladder contraction.
- Kinevac accelerates small bowel transit, reducing fluoroscopy time and radiation exposure.
- Facilitates collection of concentrated bile and pancreatic fluid for analysis.
- Paradoxical CCK responses during manometry support Kinevac's diagnostic utility in biliary dyskinesia.
Conclusions:
- Sincalide is a valuable diagnostic agent in cholecystography and small bowel imaging.
- It aids in the analysis of biliary and pancreatic secretions.
- Its provocative use in conjunction with manometry aids in diagnosing biliary dyskinesia.