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Exenatide and acute pancreatitis.
N R Tripathy1, S Basha, R Jain
1Dr. A. Ramachandran's Diabetes Hospitals, Chennai 600 008, India.
The Journal of the Association of Physicians of India
|March 28, 2009
Summary
A patient taking Exenatide (Byetta) for type 2 diabetes experienced acute pancreatitis. The drug was stopped, and the patient recovered, highlighting a potential risk associated with this medication.
Area of Science:
- Endocrinology
- Pharmacology
Background:
- Type 2 diabetes management often requires combination therapy.
- Exenatide (Byetta) is a glucagon-like peptide-1 receptor agonist used for glycemic control.
Observation:
- A female patient with a 4-year history of type 2 diabetes was prescribed Exenatide alongside Glimepiride and Metformin.
- Gastrointestinal disturbances began on the first day of Exenatide injection.
- Acute pancreatitis symptoms emerged by the eighth day, confirmed by CT scan and labs.
Findings:
- Exenatide (Byetta) administration was associated with the development of acute pancreatitis in a type 2 diabetic patient.
- Withdrawal of Exenatide led to the resolution of pancreatitis symptoms.
Implications:
- Clinicians should be vigilant for pancreatitis symptoms in patients treated with Exenatide.
- This case underscores the importance of monitoring for adverse drug reactions, particularly gastrointestinal and pancreatic events, with GLP-1 receptor agonists.
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