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Related Experiment Video

Updated: Jun 24, 2026

Experimental Approaches for Biochemical Analysis of Glial Fibrillary Acidic Protein and Its Disease-associated Variants
06:02

Experimental Approaches for Biochemical Analysis of Glial Fibrillary Acidic Protein and Its Disease-associated Variants

Published on: November 28, 2025

Alexander's law revisited.

Gary P Jacobson1, Devin L McCaslin, David M Kaylie

  • 1Vanderbilt Bill Wilkerson Center for Otolaryngology and Communication Sciences, Department of Hearing and Speech Sciences, Vanderbilt University, USA. gary.jacobson@vanderbilt.edu

Journal of the American Academy of Audiology
|March 28, 2009
PubMed
Summary
This summary is machine-generated.

Differentiating peripheral from central vestibular disorders is crucial. Spontaneous nystagmus (SN) from peripheral impairment augments in the dark, while central nystagmus does not, aiding diagnosis.

Related Experiment Videos

Last Updated: Jun 24, 2026

Experimental Approaches for Biochemical Analysis of Glial Fibrillary Acidic Protein and Its Disease-associated Variants
06:02

Experimental Approaches for Biochemical Analysis of Glial Fibrillary Acidic Protein and Its Disease-associated Variants

Published on: November 28, 2025

Area of Science:

  • Neurology
  • Ophthalmology
  • Vestibular System Science

Background:

  • Evaluating patients with unilateral vestibular system impairment requires distinguishing spontaneous nystagmus (SN) from peripheral causes versus gaze-evoked nystagmus (GEN) from central disorders.
  • Alexander's Law (AL) is typically used to identify SN from peripheral vestibular issues.

Observation:

  • This study describes a fourth element of Alexander's Law (AL): the augmentation of spontaneous nystagmus (SN) in the vision-denied condition.
  • Two cases are presented where nystagmus followed AL, but one originated from peripheral vestibular impairment and the other from a central lesion.

Findings:

  • The nystagmus in the peripheral vestibular impairment case intensified in the vision-denied condition.
  • The nystagmus in the central disorder case (asymmetric GEN) did not augment and either decreased or disappeared in the vision-denied condition.

Implications:

  • The response of SN to vision denial is key to differentiating peripheral from central vestibular disorders.
  • Augmentation of SN in the vision-denied condition suggests peripheral vestibular system impairment, while non-augmentation indicates a central eye movement disorder.