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Updated: Jun 24, 2026

Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice
Published on: July 5, 2021
[Theoretical and experimental study of the sinoatrial node pacemaker cell response modality in vagal stimulation]
Abstract:
We studied electrical activity of the SAN pacemaker cells under the influence of ACh released after stimulations of the vagus nerves, by means of mathematical modeling and experimental research. We show the reaction of the pacemaker cells being affected by both the phase and the duration of stimulation. We plotted curves of phase sensitivity of pacemakers to vagal stimulation. The paradoxal positive chronotropic effect occurred during a short vagal stimulation.
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