Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

Angle Closure Glaucoma: Treatment

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

Indirect-Acting Cholinergic Agonists: Pharmacological Actions

Indirect-Acting Cholinergic Agonists: Pharmacological Actions

Indirect-acting cholinergic agonists, also known as anticholinesterases, exert their pharmacological effects by enhancing cholinergic transmission in various body parts, including the neuromuscular junction, autonomic cholinergic synapses, and the brain.
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Glaucoma Management in Sturge-Weber Syndrome Using the Delphi Process.

Ophthalmology. Glaucoma·2025

Same author

Refractive Change at 5 Years in the Toddler Aphakia and Pseudophakia Study.

Ophthalmology·2024

Same author

Systolic hypertension as side effect of topical low dose atropine drops.

American journal of ophthalmology case reports·2024

Same author

Glaucoma-Related Adverse Events at 10 Years in the Infant Aphakia Treatment Study: A Secondary Analysis of a Randomized Clinical Trial.

JAMA ophthalmology·2020

Same author

Outcomes of Bilateral Cataract Surgery in Infants 7 to 24 Months of Age Using the Toddler Aphakia and Pseudophakia Treatment Study Registry.

Ophthalmology·2020

Same author

Complications at 10 Years of Follow-up in the Infant Aphakia Treatment Study.

Ophthalmology·2020

Search research articles

Related Experiment Video

Updated: Jun 24, 2026

The Measurement and Treatment of Suppression in Amblyopia

The Measurement and Treatment of Suppression in Amblyopia

Published on: December 14, 2012

Reverse amblyopia with atropine treatment.

Bryan C Hainline¹, Derek C Sprunger, David A Plager

¹Department of Ophthalmology Indiana University, Indianapolis, Indiana 46290, USA.

Binocular Vision & Strabismus Quarterly

|March 28, 2009

Summary

This summary is machine-generated.

Amblyopia treatments including atropine, occlusion, and combined therapy showed similar vision improvements. Younger, highly hyperopic patients with strabismic amblyopia on daily atropine faced higher risks of reverse amblyopia.

Related Experiment Videos

Last Updated: Jun 24, 2026

The Measurement and Treatment of Suppression in Amblyopia

The Measurement and Treatment of Suppression in Amblyopia

Published on: December 14, 2012

Area of Science:

Ophthalmology
Pediatric Ophthalmology
Vision Science

Background:

Amblyopia treatment effectiveness is established for occlusion, pharmacologic penalization, and combined therapy.
Concerns exist regarding treatment effectiveness and complications without standardized protocols.

Purpose of the Study:

To evaluate the effectiveness and complications of different amblyopia treatment modalities in a community-based ophthalmology practice.
To identify risk factors for reverse amblyopia development.

Main Methods:

Retrospective chart review of 133 patients treated for amblyopia.
Evaluated treatments included occlusion only, atropine penalization, and combined occlusion and atropine.
Defined reverse amblyopia as a 3 LogMar unit worsening of the sound eye's visual acuity post-treatment.

Main Results:

Vision improvement after 6 months and 1 year was comparable across atropine, occlusion, and combined therapy groups.
Eight patients (6%) developed reverse amblyopia; these were younger (mean age 3.5 years), had strabismic amblyopia, and significant hyperopic refractive errors.
Reverse amblyopia did not occur in the occlusion-only group.

Conclusions:

Atropine, patching, and combination therapy are equally effective for amblyopia treatment in this setting.
Young, highly hyperopic children with dense, strabismic amblyopia on daily atropine are at increased risk for reverse amblyopia.