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Published on: May 10, 2024
Signs and symptoms that precede wheezing in children with a pattern of moderate-to-severe intermittent wheezing
Katherine Rivera-Spoljaric1, Vernon M Chinchilli, Lindsay J Camera
1Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110-1077, USA. rivera_k@kids.wustl.edu
Insights
Significant cough is the most reliable early sign predicting wheezing in young children with a history of wheezing. This finding can help in managing respiratory tract illnesses and preventing wheezing episodes.
Area of Science:
- Pediatric respiratory health
- Clinical symptomology research
Background:
- Wheezing is common in preschool children.
- Identifying early signs of wheezing is crucial for timely intervention.
Purpose of the Study:
- To investigate parent-reported symptoms preceding wheezing in young children.
- To assess the predictive value of symptom patterns for wheezing events.
Main Methods:
- Parents of 238 children (12-59 months) with prior wheezing completed surveys on illness symptoms.
- Statistical analysis calculated sensitivity, specificity, and predictive values for symptoms preceding wheezing.
Main Results:
- Nose symptoms were most common (41%), followed by significant cough (29%).
- Significant cough demonstrated the highest predictive value for wheezing (PPV 74%, specificity 78%).
Conclusions:
- Significant cough is the most dependable indicator of impending wheezing during respiratory tract infections.
- Individualized symptom pattern analysis may improve management strategies for wheezing.
Objectives:
To examine parent-reported signs and symptoms as antecedents of wheezing in preschool children with previous moderate to severe wheezing episodes, and to determine the predictive capacity of these symptom patterns for wheezing events.
Study Design:
Parents (n = 238) of children age 12 to 59 months with moderate-to-severe intermittent wheezing enrolled in a year-long clinical trial completed surveys that captured signs and symptoms at the start of a respiratory tract illness (RTI). Sensitivity, specificity, negative predictive value, and positive predictive value (PPV) for each symptom leading to wheezing during that RTI were calculated.
Results:
The most commonly reported first symptom categories during the first RTI were "nose symptoms" (41%), "significant cough" (29%), and "insignificant cough" (13%). The most reliable predictor of subsequent wheezing was significant cough, which had a specificity of 78% and a PPV of 74% for predicting wheezing.
Conclusions:
Significant cough is the most reliable antecedent of wheezing during an RTI. It may be useful to consider individualized symptom patterns as a component of management plans intended to minimize wheezing episodes.
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